Imagene Co.,Ltd.
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Novel Chiral Building Blocks
Novel Technology
Technical Notes
Core Chiral Scaffolds
Custom Synthesis

New C-3 Chiral Building Blocks : Chiral Aziridine-2-Carboxylates

We introduce enantiomerically pure aziridine-2-carboxylates as new C-3 chiral building blocks which easily lead to various optically pure nitrogen containing molecules including natural and unnatural a- and b-amino acid derivatives.

Some of our core aziridine derivatives (both enantiomers of aziridine-2-carboxylates, aziridine-2-carboxamides, 2-hydroxymethylazirdines, 4-chloromethyl-1,3-oxazolidin-2-ones, 5-hydroxymethyl-1,3-oxazolidin-2-ones) are available from Sigma-Aldrich Co. ( as reagents to help your research.

Complete set of opposite isomers are also available from
2(R)-isomer of the aziridine-2-carboxylate in the same manner.

Novel Aziridine Chemistry I : Oxazolidinones

Various enantiomerically pure functionalized oxazolidinones are available up to Kg scale using our own aziridine technology. Some examples are shown below.

Ask oxazolidinone chemistry to us

Functionalized oxazolidin-2-ones are available

Novel Aziridine Chemistry II : 2,3-Diaminopropanoic acid

We offer 2-azido-3-aminopropanoates with +99% optical purity and would be pleased to perform customized syntheses of these molecules to help your process development and to provide you chiral building blocks

Following 2-azido-3-aminopropanoates are commercially available now

We can offer you chiral diaminopropionates with two different amides.

Novel Aziridine Chemistry III : Imidazolidinones & Imidazolidinediones

We provide uniquely functionalized chiral imidazolidinones containing three randomization points with +99% optical purity

Active research is undergoing to provide the following functionalized imidazolidinediones

Novel Aziridine Chemistry IV : Sphingosines & Ceramides

Sphingosine is a well-known constituent of cell membranes and the precursor of ceramides. All stereoisomers including their derivatives and homologues are available with more than +99% of assay and optical purity. We offer diverse sphingosines and ceramides for new drug or functional cosmetic targets.

Also all four stereoisomers of dihydrosphingosines and their corresponding ceramides are available

All isomers with different chain length are also available.

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